Spinal cord - skeletal muscle cocultures detect muscle-relaxant action of botulinum neurotoxin A
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منابع مشابه
Spinal cord--skeletal muscle cocultures detect muscle-relaxant action of botulinum neurotoxin A.
The mouse LD50 assay is routinely used for potency testing of botulinum toxins. Unfortunately, this test is associated with severe pain and distress in animals and requires large quantities of mice. Here we used cocultures of spinal cord and muscle tissue as an alternative for probing botulinum toxins. Cocultures were prepared from mouse embryonic tissue (C57/BL6J) and cultured for 24-27 days. ...
متن کاملSpinal cord - skeletal muscle cocultures detect muscle - relaxant action of botulinum neurotoxin A 1
The mouse LD50 assay is routinely used for potency testing of botulinum toxins. Unfortunately, this test is associated with severe pain and distress in animals and requires large quantities of mice. Here we used cocultures of spinal cord and muscle tissue as an alternative for probing botulinum toxins. Cocultures were prepared from mouse embryonic tissue (C57/BL6J) and cultured for 24-27 days. ...
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ژورنال
عنوان ژورنال: ALTEX
سال: 2014
ISSN: 1868-596X
DOI: 10.14573/altex.1304291